Tri-layered Electrospinning to Mimic Native Arterial Architecture using Polycaprolactone, Elastin, and Collagen: A Preliminary Study
نویسندگان
چکیده
منابع مشابه
Electrospinning collagen and elastin: preliminary vascular tissue engineering.
Significant challenges must be overcome before the true benefit and economic impact of vascular tissue engineering can be fully realized. Toward that end, we have pioneered the electrospinning of micro- and nano-fibrous scaffoldings from the natural polymers collagen and elastin and applied these to development of biomimicking vascular tissue engineered constructs. The vascular wall composition...
متن کاملArterial extracellular matrix: a mechanobiological study of the contributions and interactions of elastin and collagen.
The complex network structure of elastin and collagen extracellular matrix (ECM) forms the primary load bearing components in the arterial wall. The structural and mechanobiological interactions between elastin and collagen are important for properly functioning arteries. Here, we examined the elastin and collagen organization, realignment, and recruitment by coupling mechanical loading and mul...
متن کاملElectrospinning collagen and elastin for tissue engineering small diameter blood vessels.
Nonwoven fibrous matrices of collagen and elastin have been prepared by means of electrospinning. Variations in the morphology of the scaffolds have been evaluated as a function of the ratio of the two proteins. Scaffolds having an architecture resembling the media of natural blood vessels have been obtained. Crosslinking has been used as a valuable method to improve the stability of such matri...
متن کاملCollagen and elastin fibres.
PROCOLLAGEN-COLLAGEN CONVERSION The first extracellular step after secretion is the proteolytic cleavage of these Nand C-terminal nonhelical regions of procollagen (Bornstein, 1974). The actual location of cleavage of these extension peptides is not known, but they are probably removed during the formation of the fibre and may take part in fibrogenesis. The intermediates in the conversion of pr...
متن کاملA hyperstable collagen mimic.
BACKGROUND Collagen is the most abundant protein in animals. Each polypeptide chain of collagen is composed of repeats of the sequence: Gly-X-Y, where X and Y are often L-proline (Pro) and 4(R)-hydroxy-L-proline (Hyp) residues, respectively. These chains are wound into tight triple helices of great stability. The hydroxyl group of Hyp residues contributes much to this conformational stability. ...
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ژورنال
عنوان ژورنال: Journal of Visualized Experiments
سال: 2011
ISSN: 1940-087X
DOI: 10.3791/2084